Sriram et al., "The interplay of sex and genotype in disease associations: a comprehensive network analysis in the UK Biobank" (2025)

Vivek Sriram, Jakob Woerner, Yong-Yeol Ahn, and Dokyoon Kim, Human Genomics 19(1), 4 (2025)
DOI | PDF | Data | Code | Viz (Female, Male)

@article{sriram2025interplay,
    author = {Vivek Sriram and Jakob Woerner and Yong-Yeol Ahn and Dokyoon Kim},
    title = {The interplay of sex and genotype in disease associations: a comprehensive network analysis in the UK Biobank},
    journal = {Human Genomics},
    volume = {19},
    number = {1},
    pages = {4},
    doi = {10.1186/s40246-024-00710-9},
    year = {2025},
}

Precision medicine

Using sex-stratified UK Biobank association results, the paper builds male- and female-specific disease-disease networks for 103 diseases. The networks share broad topology but differ in how diseases connect and cluster, supporting closer attention to genotype-by-sex interactions in cross-phenotype associations and Precision medicine.